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By Ashkenazi A.

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Proceedings 13th Congress of ESMO, 1988, abstract No 182 Resistance to Antioestrogen Therapy: a Challenge for the Future V. A. The Current Clinical Situation Tamoxifen (Nolvadex@) is the first-line endocrine therapy for advanced breast cancer. About 30% of unselected patients have an objective response, although another 20% have stable disease. If oestrogen receptor-positive patients are selected for study, tamoxifen produces a 50-60% objective response rate. Nevertheless, about 13% of oestrogen receptor-negative patients can have a response to therapy.

Table 1 summarises the results in different series of New Developments in the Field of Aromatase Inhibitors 47 Table 1. Results in different series of patients treated with second-line aminoglutethimide Reference [7] [6] [11 ] [27] [22] [26] [25] [24] No. 5 11 CR+ PR(%) a) Total series b) Site of lesions Viscera Bone Soft tissue Duration of response, median in months patients treated with second-line AG also with regard to the site of the lesions. Currently the results correlating antitumour activity of AG and tumour level of aromatase are scanty and inconsistent.

In: Proc of the 3rd International Conference on Adjuvant Therapy of Primary Breast Cancer. St Gallen 1988 p 4 24 Hovus AG, Hutter RVP, Berg JW: Significance of axillary macro metastases and micrometastases in mammary cancer. Ann Surg 1971 (173):44-46 25 Fisher ER, Swamidoss S, Lee CH et al: Detection and significance of occult axillary node metastases in patients with invasive breast cancer. Cancer 1978 (42):2025-2031 26 Rosen PP, Saigo PE, Brown DW Jr et al: Prognosis in stage \I (T1 N1 MO) breast cancer.

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Apo2L/TRAIL by Ashkenazi A.


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