By William M. Lee, Roger Williams, Jean-Pierre Benhamou, Jacques Bernuau
Acute liver failure (ALF), or fulminant hepatic failure, is a unique medical syndrome that crosses scientific disciplines. a comparatively infrequent , ALF continues to be a massive concentration of scientific and study cognizance. With the appearance of transplantation, the significance of figuring out administration of ALF has taken on a brand new urgency. during this first quantity devoted to ALF, the editors collect a unusual group of members to explain the etiology, pathology and therapy of this crucial syndrome. additionally coated are consensus suggestions in liver transplantation for ALF sufferers, in addition to descriptions of man-made and bioartificial liver support units. a piece on destiny remedies comprises hepatocyte transplantation, auxiliary grafts and different transitority liver help. amazing for the excessive point of the authors' services, this complete quantity may still end up helpful.
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Additional info for Acute Liver Failure
Schaffner, 282-98. New York: Grune and Stratton. , Roberts, J. and Lake, J. 1991. Hepatitis C virus not found in fulminant non-A non-B hepatitis. Ann Intern Med 115: 111-12. , Ohnishi, H. and Muto, Y. 1991. Hepatitis C virus in fulminant hepatic failure. N EngIJMedl24: 1895-6. , Okamoto, H. and Mayumi, M. 1994. Contribution of hepatitis C virus to non-A non-B fulminant hepatitis in Japan. Hepatology 19:829-35. 2 Viral hepatitis and acute liver failure Dwain L. Thiele INTRODUCTION Table 2 . 1 . Etiologies offulminant viral hepatitis Acute liver failure is a rare complication of acute viral hepatitis.
1993). The generation of trifluoroacetylated microsomal proteins occurs in all anesthetized subjects but overt liver disease is very rare (1:30,000 with single exposure and 1:3,000 with multiple exposures). Multiple different antigens have been identified from the purified microsomal proteins identified by immunoreactivity with patient antisera, including microsomal carboxylesterase, protein disulfide isomerase, and pyruvate dehydrogenase complex-lipoic acid, and these are expressed on the cell surface normally to a small extent (Gut et al.
Since the ultimate and full extent of liver injury involves these extra-hepatocyte events, targeting therapy or prevention of hepatotoxicity toward blocking tumor necrosis factor (TNF) or leukocyte adhesion appears to be a fruitful area for future clinical investigation. PREDICTABLE VERSUS UNPREDICTABLE HEPATOTOXICITY Hepatotoxicity from drugs can be viewed as predictable or unpredictable. Predictable injury is dose-related, usually reproducible in animal models and the liver injury is due to the intrinsic toxicity of a drug or its metabolites.
Acute Liver Failure by William M. Lee, Roger Williams, Jean-Pierre Benhamou, Jacques Bernuau