Get A Handbook for DNA-Encoded Chemistry: Theory and PDF

By Robert A. Goodnow Jr.

ISBN-10: 1118487680

ISBN-13: 9781118487686

This ebook comprehensively describes the improvement and perform of DNA-encoded library synthesis know-how. jointly, the chapters aspect an method of drug discovery that gives an enticing addition to the portfolio of latest hit iteration applied sciences similar to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a necessary consultant for figuring out and utilizing DNA-encoded combinatorial chemistry
  • Helps chemists generate and display novel chemical libraries of enormous dimension and caliber
  • Bridges interdisciplinary components of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists the best way to successfully increase on hand “chemical area” for drug discovery
  • Provides professional and up to date precis of suggested literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Additional resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

Sample text

Tartaro, K. , Vogt, K. , Volkmer, G. , Wang, S. , Weiner, M. , Begley, R. , Rothberg, J. M. (2005). Genome sequencing in microfabricated high-density picolitre reactors. Nature, 437, 376–380. 31. , Kinzler, K. , Vogelstein, B. (2003). Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc. Natl. Acad. Sci. , 100, 8817–8822. 32. , Nyren, P. (1998). A sequencing method based on real-time pyrophosphate. Science, 281, 363–365.

Transient blocking of the 3′-hydroxyl group of reversible terminators ensures that the synthesis is temporarily halted after single nucleotide incorporation, allowing for image acquisition. The 454 sequencing platform [30] is based on a similar strategy: separation of DNA fragments and their amplification, followed by parallel sequencing by synthesis. The DNA fragments are amplified by emulsion PCR [31] and then sequenced by pyrosequencing method [32]. At low template concentration, emulsion PCR is a clonal amplification method carried out in a water-in-oil emulsion.

The key to understanding how hereditary information is encoded and why DNA is uniquely suited for storage of genetic instructions lies in its composition and structure. DNA is a linear polymer built from monomers called nucleotides. Synthetic DNA molecules, usually containing fewer than 200 nucleotides, are known as oligonucleotides. Often, oligonucleotides are described in terms of “mers,” referring to the number of nucleotides within the oligonucleotide. For example, 12-mer will ­contain 12 nucleotides in its structure.

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A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery by Robert A. Goodnow Jr.


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